Hmmm... Easiest: I'd say... Umm... How was it called? Oh, Evrae Altana or something like that from FFX, you just gave him a Phoenix Down and he's dead ¬¬. Same goes to the Fake President and the fishy skeleton thing from FF8, and that thing in the Cave of the Gi from FF7.
Hardest: I say Emerald Weapon from FF7. Omega from FF8 wasn't hard with my strategy (Holy Wars, Lionheart, Eden, Shot), neither was Nemesis from FFX (Quick Hit til dead, summon Aeons to defend), haven't played the others. Althrough Des Ritcher from FFX International should be really hard, but I never played it ¬¬.